Inherited genetic variations have a major impact on childhood leukemia risk

Mar. 19, 2013 ? Humans have between 20,000 and 25,000 genes that carry instructions for assembling the proteins that do the work of cells. Work led by St. Jude Children's Research Hospital found that children who inherit certain variations in four particular genes are at much higher risk of developing acute lymphoblastic leukemia (ALL).

The study also showed that Hispanic patients were more likely than patients of European or African ancestry to inherit high-risk versions of two of these genes. ALL rates are known to be higher among Hispanic children than those of European or African ancestry, this discovery points to at least one reason for that difference.

Each person's genome includes two copies of each gene, one from each parent. Thus, individuals could inherit up to eight high-risk versions of the four genes tied to an increased ALL risk. In this study, researchers found that having more than five copies of the risk genes resulted in a nine-fold greater risk of developing ALL in childhood than inheriting no more than one copy.

The report appears online March 19 in the Journal of the National Cancer Institute.

The findings stem from one of the largest multi-ethnic studies of genetic variation and ALL susceptibility ever conducted. The work included 2,450 pediatric ALL patients and 10,977 individuals from diverse racial and ethnic backgrounds without the disease.

The study's senior author, Jun J. Yang, Ph.D., an assistant member of the St. Jude Department of Pharmaceutical Sciences, said that the absolute risk for a particular child of developing ALL remains low. "ALL is a complex disease that likely involves many genes," he said. "The discoveries we are reporting in this paper are an important step forward in terms of understanding why children develop ALL in the first place, particularly for those with African or Hispanic ethnicity. However, this is probably still just a small part of the complete picture."

Along with providing insight into ethnicity and ALL risk, the study also offered clues to understanding the age pattern of ALL, which peaks in children ages 2 to 4. These findings suggest that younger patients might be most vulnerable to the effects of the high-risk gene variations.

This year about 3,000 children in the U.S. will be diagnosed with ALL, making it the most common childhood cancer. It is also among the most curable. Evidence that inheritance plays a role in childhood ALL risk has been building in recent years, but previous studies focused almost exclusively on patients of European ancestry. Thanks in part to new statistical methods for studying genetic variation in more diverse populations, this study expanded the quest to understand the genetic basis of ALL risk to include patients of African and Hispanic as well as European ancestry.

The effort involved ALL patients treated at St. Jude and through the Children's Oncology Group, the world's largest cooperative pediatric cancer research organization, As a comparison, investigators also screened DNA from individuals without ALL. Researchers used an automated system to check each person's DNA for 709,059 gene variations. In this study, ethnicity was assigned based on gene variations representative of European, African and Native American ancestry.

Previous studies from St. Jude and others linked pediatric ALL risk to common differences in the ARID5B, IKZF1, CEBPE and CDKN2A/2B genes. All play a role in normal blood and immune system development. ALL is a cancer of certain immune cells. In this study, researchers also discovered several variations in the gene PIP4K2A, which were associated with an elevated pediatric ALL risk. Hispanic patients were more likely than others in this study to inherit high-risk versions of the ARID5B and PIP4K2A genes, while African-American patients were less likely to have these variants.

The study's first authors are Heng Xu and Wenjian Yang, both of St. Jude. The other authors are Virginia Perez-Andreu, Yiping Fan, Cheng Cheng, Deqing Pei, Charles Mullighan, Deepa Bhojwani, Ching-Hon Pui, William Evans and Mary Relling, all of St. Jude; Meenakshi Devidas, University of Florida, Gainesville; Paul Scheet, University of Texas MD Anderson Cancer Center, Houston; Esteban Gonzalez Burchard, Celeste Eng, Scott Huntsman, Dara Torgerson and Mignon Loh, all of the University of California, San Francisco; Michael Dean, National Cancer Institute; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Paul Martin, Duke University, Durham, N.C.; Bruce Camitta, Medical College of Wisconsin; W. Paul Bowman, Cook Children's Medical Center, Ft. Worth; Cheryl Willman, University of New Mexico, Albuquerque; William Carroll, New York University; and Stephen Hunger, University of Colorado, Aurora.

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The above story is reprinted from materials provided by St. Jude Children's Research Hospital.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/jUB8fBTlyS0/130319201943.htm

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Planning A Home Improvement Project? Read This Advice

Learn all you can about home improvement and forget others' inputs. This article is going to help you with some great tips you can use.

Remember that safety in mind when you do any home improvement. There is some danger in any home improvement project you do, so make sure to read the instructions on power tools and ask for help from store associates if you need it. You can also use the Internet to find informative tutorials to get additional help.

You can significantly improve the look of a room with new window treatments. You can even make a set for different seasons if you want.

You should take a close look at the foundation of your home to see if there are any cracks before cold weather sets in. Pests such as rodents, rodents and insects seek cover in places that are warm during the winter, and sealing up any potential entry points will help to keep your home free of these unwanted critters.

Disconnect and clean your existing dryer hose. Cut the hose until it is just a few feet. It should allow for the machine to be pulled out for cleaning, since a short hose will run more efficiently.

Adding a new sink can help spruce up your kitchen. This can instantly improve your kitchen. Sinks nowadays are available in a number of colors, styles and shapes.

You might not be able to use the kitchen equipment.

Many of the normal home improvement jobs can be done by yourself. You might be able to paint, do simple repairs to your plumbing, and easy plumbing fixes. You can save a lot of money in your pocket if you do these things by yourself.

Never underestimate the important of a quality doors. Your guests will be impressed by it because they enter and leave your home. You may be losing a lot of the heat through a poorly fit and uninsulated door. A ratty door frame or the locks are not recent.

If you're buying a new home, be sure to look at the ceilings, chipped paint and more. However, electrical issues, bad wiring, foundation damage and other issues require an inspector to notice.

Use empty baby food glass jars to add organization to your workspace. Screw or glue the jar lids into the shelf. You can use these jars to store different items in the jars. This is a good way to maximize shelving and recycle the jars you might not use otherwise.

Ceramic tiles can begin to dull and look grungy as time goes on. A solution of vinegar and water will safely clean most floors.Fill a bucket with the solution and start mopping your floor. The solution eliminates dirt and grime easily to help put a shine on your floor shining.

Planting a small tree is a great way to make your landscape more interesting. Landscaping can help to make the most of your home's value. The tree you grow make great mature shade trees. You can also save when it comes to cooling costs with a tree in the right place.

Reuse whatever you can when undertaking a home improvement work to get the maximum savings and the minimum environmental impact.Why not paint cabinets to update their look?You can also make your cabinets to a more modern by replacing their knobs or knobs.

If your house is several years old, you should insulate your pipes again. The insulation can often become worn and even fall off the pipes as a home ages. To make sure your pipes don't freeze in the winter, upgrade the insulation.

Talk to your neighbor about drainage before you start a major landscaping project. A good plan will keep your property well drained.

Think green when it comes to home improvements. This can effectively add value to your home. Installing an air conditioning system or furnace that is energy efficient creates a more comfortable living space, as well as save money and help the environment.

You need to do your research before demolishing anything. Always check first for electrical wiring and components. It may be costly to remove the entire structure, which is why you should check this out first.

You need to think about more than cost when you are checking out contractor quotes. There are lots of factors you should compare like labor costs, labor cost, warranties, and how long the company has been in business. You also need to think about how much the project cost with the emotional toll it will have on you.

Major home improvements generally need permits and permission from your local Council before beginning any work. If you are having a hard time figuring out exactly what you need to do, hire a professional to assist you to avoid costly mistakes or fines at a later date.

You can make your home's value by re-finishing the hardwood floors. You can find the proper equipment and maybe even take classes at a hardware store near you. This can save you a lot of money in the long run.

In summary, you've just gotten some great ideas about home improvement. Whether you've picked up an idea for an entirely new project or just learned some nifty ways to save additional time and money, educating yourself on the topic of home improvement is never a waste of time. Utilize the information you've learned to help you reach success.

Tagged as: garden, house, interior design

Source: http://yarwoodrealestate.com/planning-a-home-improvement-project-read-this-advice/

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ScienceDaily: Child Development News

http://www.sciencedaily.com/news/mind_brain/child_development/ Read the latest research in child development including how newborns learn to think, how sleep patterns emerge, problems with toddlers and more.en-usMon, 18 Mar 2013 03:28:55 EDTMon, 18 Mar 2013 03:28:55 EDT60http://www.sciencedaily.com/images/logosmall.gifhttp://www.sciencedaily.com/news/mind_brain/child_development/ For more science articles, visit ScienceDaily.http://www.sciencedaily.com/releases/2013/03/130315202640.htm Teens who were depressed as children are far more likely than their peers to be obese, smoke cigarettes and lead sedentary lives, even if they no longer suffer from depression. The research suggests that depression, even in children, can increase the risk of heart problems later in life.Fri, 15 Mar 2013 20:26:26 EDThttp://www.sciencedaily.com/releases/2013/03/130315202640.htmhttp://www.sciencedaily.com/releases/2013/03/130315150855.htm More benefit/risk information is needed in community care efforts, says a researcher.Fri, 15 Mar 2013 15:08:08 EDThttp://www.sciencedaily.com/releases/2013/03/130315150855.htmhttp://www.sciencedaily.com/releases/2013/03/130314175704.htm While poverty and under-education continue to dampen contraception use in Nepal, exacerbating the country?s efforts to reduce maternal and child mortality rates, researchers say another, more surprising factor may be more intractable: Deeply held cultural preferences for sons over daughters.Thu, 14 Mar 2013 17:57:57 EDThttp://www.sciencedaily.com/releases/2013/03/130314175704.htmhttp://www.sciencedaily.com/releases/2013/03/130314124618.htm A surprisingly high number of women have postpartum depression, reports a new, large-scale study of 10,000 women. A high rate of women had considered harming themselves. The study's screening likely saved several lives. Most postpartum women with depression are not identified or treated even though they are at a higher risk for psychiatric disorders. It's a major public health problem because a woman's mental health affects her child's physical and emotional development.Thu, 14 Mar 2013 12:46:46 EDThttp://www.sciencedaily.com/releases/2013/03/130314124618.htmhttp://www.sciencedaily.com/releases/2013/03/130314110249.htm Researchers have developed a non-invasive optical measurement system to monitor neonatal brain activity via cerebral metabolism and blood flow.Thu, 14 Mar 2013 11:02:02 EDThttp://www.sciencedaily.com/releases/2013/03/130314110249.htmhttp://www.sciencedaily.com/releases/2013/03/130314085059.htm Linguists have found evidence of how people form into tribe-like communities on social network sites such as Twitter.Thu, 14 Mar 2013 08:50:50 EDThttp://www.sciencedaily.com/releases/2013/03/130314085059.htmhttp://www.sciencedaily.com/releases/2013/03/130313182022.htm The practice of prescribing drugs to boost cognitive function, or memory and thinking abilities, in healthy children and teens is misguided, according to a new statement by the American Academy of Neurology.Wed, 13 Mar 2013 18:20:20 EDThttp://www.sciencedaily.com/releases/2013/03/130313182022.htmhttp://www.sciencedaily.com/releases/2013/03/130313182019.htm Autism results from abnormal cell communication. Testing a new theory, researchers have used a newly discovered function of an old drug to restore cell communications in a mouse model of autism, reversing symptoms of the devastating disorder.Wed, 13 Mar 2013 18:20:20 EDThttp://www.sciencedaily.com/releases/2013/03/130313182019.htmhttp://www.sciencedaily.com/releases/2013/03/130313123540.htm Autism spectrum disorders affect the brain activity of children and adults differently, according to new research.Wed, 13 Mar 2013 12:35:35 EDThttp://www.sciencedaily.com/releases/2013/03/130313123540.htmhttp://www.sciencedaily.com/releases/2013/03/130313123313.htm The stick can work just as well as the carrot in improving our performance, a team of academics has found.Wed, 13 Mar 2013 12:33:33 EDThttp://www.sciencedaily.com/releases/2013/03/130313123313.htmhttp://www.sciencedaily.com/releases/2013/03/130313095533.htm Gamma-aminobutyric acid (GABA) deficits have been implicated in schizophrenia and depression. In schizophrenia, deficits have been particularly well-described for a subtype of GABA neuron, the parvalbumin fast-spiking interneurons. The activity of these neurons is critical for proper cognitive and emotional functioning. It now appears that parvalbumin neurons are particularly vulnerable to oxidative stress, a factor that may emerge commonly in development, particularly in the context of psychiatric disorders like schizophrenia or bipolar disorder, where compromised mitochondrial function plays a role.Wed, 13 Mar 2013 09:55:55 EDThttp://www.sciencedaily.com/releases/2013/03/130313095533.htmhttp://www.sciencedaily.com/releases/2013/03/130312152049.htm Children with an autism spectrum disorder may be at greater risk for contemplating suicide or attempting suicide than children without autism, according to researchers.Tue, 12 Mar 2013 15:20:20 EDThttp://www.sciencedaily.com/releases/2013/03/130312152049.htmhttp://www.sciencedaily.com/releases/2013/03/130312152002.htm Children as young as 3 years old know when they are not sure about a decision, and can use that uncertainty to guide decision making, according to new research.Tue, 12 Mar 2013 15:20:20 EDThttp://www.sciencedaily.com/releases/2013/03/130312152002.htmhttp://www.sciencedaily.com/releases/2013/03/130311201142.htm UK children are being exposed to millions of tobacco images/messages every week on prime time television, indicates new research.Mon, 11 Mar 2013 20:11:11 EDThttp://www.sciencedaily.com/releases/2013/03/130311201142.htmhttp://www.sciencedaily.com/releases/2013/03/130311201019.htm Children who avoid situations they find scary are likely to have anxiety a study of more than 800 children ages 7 to 18 found.Mon, 11 Mar 2013 20:10:10 EDThttp://www.sciencedaily.com/releases/2013/03/130311201019.htmhttp://www.sciencedaily.com/releases/2013/03/130308103414.htm Psychologists demonstrate the impact sensitive parenting has on language growth for children who receive cochlear implants.Fri, 08 Mar 2013 10:34:34 ESThttp://www.sciencedaily.com/releases/2013/03/130308103414.htmhttp://www.sciencedaily.com/releases/2013/03/130307123947.htm What happens when human brain cells that surround and support neurons are implanted into the brains of newborn mice? Researchers recently found that such mice had enhanced learning and memory when compared with normal mice that hadn't received the transplanted human cells. The findings indicate that these supportive cells, called glia, play an important role in human cognition.Thu, 07 Mar 2013 12:39:39 ESThttp://www.sciencedaily.com/releases/2013/03/130307123947.htmhttp://www.sciencedaily.com/releases/2013/03/130307123944.htm A new study explains how young brains are protected when nutrition is poor. The findings reveal a coping strategy for producing a fully functional, if smaller, brain. The discovery, which was made in larval flies, shows the brain as an incredibly adaptable organ and may have implications for understanding the developing human brain as well, the researchers say.Thu, 07 Mar 2013 12:39:39 ESThttp://www.sciencedaily.com/releases/2013/03/130307123944.htmhttp://www.sciencedaily.com/releases/2013/03/130307091552.htm Exercise may play a key role in helping children cope with stressful situations, according to a recent study.Thu, 07 Mar 2013 09:15:15 ESThttp://www.sciencedaily.com/releases/2013/03/130307091552.htmhttp://www.sciencedaily.com/releases/2013/03/130306134226.htm The flip of a single molecular switch helps create the mature neuronal connections that allow the brain to bridge the gap between adolescent impressionability and adult stability. Now researchers have reversed the process, recreating a youthful brain that facilitated both learning and healing in the adult mouse.Wed, 06 Mar 2013 13:42:42 ESThttp://www.sciencedaily.com/releases/2013/03/130306134226.htmhttp://www.sciencedaily.com/releases/2013/03/130306134218.htm In the din of a crowded room, paying attention to just one speaker's voice can be challenging. Research demonstrates how the brain homes in on one speaker to solve this "Cocktail Party Problem." Researchers discovered that brain waves are shaped so the brain can selectively track the sound patterns from the speaker of interest while excluding competing sounds from other speakers. The findings could have important implications for helping individuals with a range of deficits.Wed, 06 Mar 2013 13:42:42 ESThttp://www.sciencedaily.com/releases/2013/03/130306134218.htmhttp://www.sciencedaily.com/releases/2013/03/130306084154.htm Psychologists have found that children and adolescents with major depression or subthreshold forms of bipolar disorder - and who had at least one first-degree relative with bipolar disorder - responded better to a 12-session family-focused treatment than to a briefer educational treatment.Wed, 06 Mar 2013 08:41:41 ESThttp://www.sciencedaily.com/releases/2013/03/130306084154.htmhttp://www.sciencedaily.com/releases/2013/03/130306083935.htm Recent research into how we learn is set to help people in their efforts to read a second or foreign language (SFL) more effectively. This will be good news for those struggling to develop linguistic skills in preparation for a move abroad, or to help in understanding foreign language forms, reports, contracts and instructions.Wed, 06 Mar 2013 08:39:39 ESThttp://www.sciencedaily.com/releases/2013/03/130306083935.htmhttp://www.sciencedaily.com/releases/2013/03/130305174627.htm Researchers have, for the first time, identified a specific group of cells in the brainstem whose activation during rapid eye movement sleep is critical for the regulation of emotional memory processing.Tue, 05 Mar 2013 17:46:46 ESThttp://www.sciencedaily.com/releases/2013/03/130305174627.htmhttp://www.sciencedaily.com/releases/2013/03/130305091000.htm It is possible to tell who a person is thinking about by analyzing images of his or her brain. Our mental models of people produce unique patterns of brain activation, which can be detected using advanced imaging techniques according to a new study.Tue, 05 Mar 2013 09:10:10 ESThttp://www.sciencedaily.com/releases/2013/03/130305091000.htmhttp://www.sciencedaily.com/releases/2013/03/130305090956.htm Adults whose parents were divorced are more likely to switch religions or disassociate themselves from institutional religions altogether -- but growing up in a single-parent family does not have any effect on private religious life, including praying, according to a new study.Tue, 05 Mar 2013 09:09:09 ESThttp://www.sciencedaily.com/releases/2013/03/130305090956.htmhttp://www.sciencedaily.com/releases/2013/03/130304161623.htm Women who receive strong social support from their families during pregnancy appear to be protected from sharp increases in a particular stress hormone, making them less likely to develop postpartum depression, according to a new study.Mon, 04 Mar 2013 16:16:16 ESThttp://www.sciencedaily.com/releases/2013/03/130304161623.htmhttp://www.sciencedaily.com/releases/2013/03/130304151811.htm The mammalian placenta is more than just a filter through which nutrition and oxygen are passed from a mother to her unborn child. According to a new study, if a mother is exposed to stress during pregnancy, her placenta translates that experience to her fetus by altering levels of a protein that affects the developing brains of male and female offspring differently.Mon, 04 Mar 2013 15:18:18 ESThttp://www.sciencedaily.com/releases/2013/03/130304151811.htmhttp://www.sciencedaily.com/releases/2013/03/130304151807.htm A new mother may constantly worry and check to see if her baby is breathing. Or she may obsess about germs. A new study found postpartum moms have a much higher rate of obsessive-compulsive symptoms than the general population. This is the first large-scale study of obsessive-compulsive symptoms in new moms. The symptoms could result from hormonal changes or be adaptive, but may indicate a psychological disorder if they interfere with a mother's functioning.Mon, 04 Mar 2013 15:18:18 ESThttp://www.sciencedaily.com/releases/2013/03/130304151807.htmhttp://www.sciencedaily.com/releases/2013/03/130304104912.htm Study could reveals key predictors of speech gains. New findings reveal that 70 percent of children with autism spectrum disorders (ASD) who have a history of severe language delay, achieved phrase or fluent speech by age eight.Mon, 04 Mar 2013 10:49:49 ESThttp://www.sciencedaily.com/releases/2013/03/130304104912.htmhttp://www.sciencedaily.com/releases/2013/03/130304104758.htm The first large, population-based study to follow children with attention-deficit hyperactivity disorder into adulthood shows that ADHD often doesn?t go away and that children with ADHD are more likely to have other psychiatric disorders as adults. They also appear more likely to commit suicide and to be incarcerated as adults.Mon, 04 Mar 2013 10:47:47 ESThttp://www.sciencedaily.com/releases/2013/03/130304104758.htmhttp://www.sciencedaily.com/releases/2013/03/130301122512.htm The interplay between an infection during pregnancy and stress in puberty plays a key role in the development of schizophrenia, as behaviorists demonstrate in a mouse model. However, there is no need to panic.Fri, 01 Mar 2013 12:25:25 ESThttp://www.sciencedaily.com/releases/2013/03/130301122512.htmhttp://www.sciencedaily.com/releases/2013/02/130228194651.htm Children in Britain are more exposed to alcohol promotion than adults and need much stronger protection, warn experts.Thu, 28 Feb 2013 19:46:46 ESThttp://www.sciencedaily.com/releases/2013/02/130228194651.htmhttp://www.sciencedaily.com/releases/2013/02/130228124132.htm Much to the chagrin of parents who think their kids should spend less time playing video games and more time studying, time spent playing action video games can actually make dyslexic children read better, new research suggests. In fact, 12 hours of video game play did more for reading skills than is normally achieved with a year of spontaneous reading development or demanding traditional reading treatments.Thu, 28 Feb 2013 12:41:41 ESThttp://www.sciencedaily.com/releases/2013/02/130228124132.htmhttp://www.sciencedaily.com/releases/2013/02/130228113449.htm A new study from Israel says that children with learning disabilities develop less secure attachments with mothers and teachers, and that closer and more secure relationships with parents and adults may help them overcome these disabilities.Thu, 28 Feb 2013 11:34:34 ESThttp://www.sciencedaily.com/releases/2013/02/130228113449.htmhttp://www.sciencedaily.com/releases/2013/02/130228103443.htm A healthy diet during pregnancy is critical to the future health of your children. New research suggests that pregnant mothers who consume junk food cause developmental changes of the opioid signaling pathway in the brains of their unborn children. Consequently, these children are less sensitive to opioids released upon consumption of foods high in fat and sugar, and need to eat more to achieve a "feel good" response.Thu, 28 Feb 2013 10:34:34 ESThttp://www.sciencedaily.com/releases/2013/02/130228103443.htmhttp://www.sciencedaily.com/releases/2013/02/130227183504.htm The presence of an animal can significantly increase positive social behaviors in children with autism spectrum disorders, according to new research.Wed, 27 Feb 2013 18:35:35 ESThttp://www.sciencedaily.com/releases/2013/02/130227183504.htmhttp://www.sciencedaily.com/releases/2013/02/130227183320.htm One of literature's oldest mysteries is a step closer to being solved. A new study dates Homer's The Iliad to 762 BCE and adds a quantitative means of testing ideas about history by analyzing the evolution of language.Wed, 27 Feb 2013 18:33:33 ESThttp://www.sciencedaily.com/releases/2013/02/130227183320.htmhttp://www.sciencedaily.com/releases/2013/02/130227183316.htm Praising children, especially those with low self-esteem, for their personal qualities rather than their efforts may make them feel more ashamed when they fail, according to new research.Wed, 27 Feb 2013 18:33:33 ESThttp://www.sciencedaily.com/releases/2013/02/130227183316.htmhttp://www.sciencedaily.com/releases/2013/02/130227151302.htm Children who failed to acquire a basic math skill in first grade scored far behind their peers by seventh grade on a test of the mathematical abilities needed to function in adult life, according to researchers.Wed, 27 Feb 2013 15:13:13 ESThttp://www.sciencedaily.com/releases/2013/02/130227151302.htmhttp://www.sciencedaily.com/releases/2013/02/130227151258.htm Research indicates that half of all lifetime cases of mental illness begin by age 14, well before adulthood. Three new studies investigate the cognitive, genetic and environmental factors that may contribute to mental health disorders in adolescence.Wed, 27 Feb 2013 15:12:12 ESThttp://www.sciencedaily.com/releases/2013/02/130227151258.htmhttp://www.sciencedaily.com/releases/2013/02/130227134338.htm Neuroscientists should help to develop compelling digital games that boost brain function and improve well-being, say two professors specializing in the field.Wed, 27 Feb 2013 13:43:43 ESThttp://www.sciencedaily.com/releases/2013/02/130227134338.htmhttp://www.sciencedaily.com/releases/2013/02/130227121910.htm New research examines how childhood socioeconomic disadvantages and maternal depression increase the risk of major depression and chronic pain when they become adults.Wed, 27 Feb 2013 12:19:19 ESThttp://www.sciencedaily.com/releases/2013/02/130227121910.htmhttp://www.sciencedaily.com/releases/2013/02/130227102940.htm Most parents would agree that raising a generous child is an admirable goal -- but how, exactly, is that accomplished? New results shed light on how generosity and related behaviors -- such as kindness, caring and empathy -- develop, or don't develop, in children from 2 years old through adolescence.Wed, 27 Feb 2013 10:29:29 ESThttp://www.sciencedaily.com/releases/2013/02/130227102940.htmhttp://www.sciencedaily.com/releases/2013/02/130227102022.htm A look at how the brain processes information finds distinct pattern in autistic children. Using EEGs to track the brain's electrical cross-talk, researchers found structural difference in brain connections. Compared with neurotypical children, those with autism have multiple redundant connections between neighboring brain areas at expense of long-distance links. The study, using "network analysis" like with airlines or electrical grids, may help in understanding some classic autistic behaviors.Wed, 27 Feb 2013 10:20:20 ESThttp://www.sciencedaily.com/releases/2013/02/130227102022.htmhttp://www.sciencedaily.com/releases/2013/02/130226194006.htm A study finds an increased risk of narcolepsy in children and adolescents who received the A/H1N1 2009 influenza vaccine (Pandemrix) during the pandemic in England.Tue, 26 Feb 2013 19:40:40 ESThttp://www.sciencedaily.com/releases/2013/02/130226194006.htmhttp://www.sciencedaily.com/releases/2013/02/130226081155.htm During sleep, our brains store what we have learned during the day a process even more effective in children than in adults, new research shows.Tue, 26 Feb 2013 08:11:11 ESThttp://www.sciencedaily.com/releases/2013/02/130226081155.htmhttp://www.sciencedaily.com/releases/2013/02/130225162231.htm Researchers have found significantly higher levels of toxic metals in children with autism, compared to typical children. They hypothesize that reducing early exposure to toxic metals may help lessen symptoms of autism, though they say this hypotheses needs further examination.Mon, 25 Feb 2013 16:22:22 ESThttp://www.sciencedaily.com/releases/2013/02/130225162231.htmhttp://www.sciencedaily.com/releases/2013/02/130225162229.htm Giving back through volunteering is good for your heart, even at a young age, according to researchers.Mon, 25 Feb 2013 16:22:22 ESThttp://www.sciencedaily.com/releases/2013/02/130225162229.htmhttp://www.sciencedaily.com/releases/2013/02/130225122039.htm A new case study shows children with Down syndrome can benefit from conventional stuttering treatment.Mon, 25 Feb 2013 12:20:20 ESThttp://www.sciencedaily.com/releases/2013/02/130225122039.htmhttp://www.sciencedaily.com/releases/2013/02/130225112510.htm Low-birth-weight babies with a particular brain abnormality are at greater risk for autism, according to a new study that could provide doctors a signpost for early detection of the still poorly understood disorder.Mon, 25 Feb 2013 11:25:25 ESThttp://www.sciencedaily.com/releases/2013/02/130225112510.htmhttp://www.sciencedaily.com/releases/2013/02/130222083127.htm Parents know that one day they will have to talk to their children about drug use. The hardest part is to decide whether or not talking about ones own drug use will be useful in communicating an antidrug message. Recent research found that children whose parents did not disclose drug use, but delivered a strong antidrug message, were more likely to exhibit antidrug attitudes.Fri, 22 Feb 2013 08:31:31 ESThttp://www.sciencedaily.com/releases/2013/02/130222083127.htmhttp://www.sciencedaily.com/releases/2013/02/130221143946.htm Scientists have found compelling evidence that older adults can eliminate forgetfulness and perform as well as younger adults on memory tests. The cognitive boost comes from a surprising source -- a distraction learning strategy.Thu, 21 Feb 2013 14:39:39 ESThttp://www.sciencedaily.com/releases/2013/02/130221143946.htmhttp://www.sciencedaily.com/releases/2013/02/130221141608.htm The sounds uttered by birds offer in several respects the nearest analogy to language," Charles Darwin wrote in "The Descent of Man" (1871), while contemplating how humans learned to speak. Language, he speculated, might have had its origins in singing, which "might have given rise to words expressive of various complex emotions." Linguistics and biology now researchers propose a new theory on the deep roots of human speech.Thu, 21 Feb 2013 14:16:16 ESThttp://www.sciencedaily.com/releases/2013/02/130221141608.htmhttp://www.sciencedaily.com/releases/2013/02/130221104330.htm Early life stress like that experienced by ill newborns appears to take an early toll of the heart, affecting its ability to relax and refill with oxygen-rich blood, researchers report.Thu, 21 Feb 2013 10:43:43 ESThttp://www.sciencedaily.com/releases/2013/02/130221104330.htmhttp://www.sciencedaily.com/releases/2013/02/130220170736.htm Scientists have identified a molecular signaling pathway that plays an important role in the development of fetal alcohol spectrum disorder.Wed, 20 Feb 2013 17:07:07 ESThttp://www.sciencedaily.com/releases/2013/02/130220170736.htmhttp://www.sciencedaily.com/releases/2013/02/130220163629.htm Bullied children grow into adults who are at increased risk of developing anxiety disorders, depression and suicidal thoughts, according to a new study.Wed, 20 Feb 2013 16:36:36 ESThttp://www.sciencedaily.com/releases/2013/02/130220163629.htmhttp://www.sciencedaily.com/releases/2013/02/130220123413.htm Children with brain lesions suffered before or around the time of birth are able to use gestures -- an important aspect of the language learning process -- to convey simple sentences.Wed, 20 Feb 2013 12:34:34 ESThttp://www.sciencedaily.com/releases/2013/02/130220123413.htmhttp://www.sciencedaily.com/releases/2013/02/130219201523.htm Adding movement to mental rehearsal can improve performance finds a new study. For high jumpers the study shows that dynamic imagery improves the number of successful attempts and the technical performance of jumps The technique of mental rehearsal is used to consolidate performance in many disciplines including music and sport. Motor imagery and physical practice use overlapping neural networks in the brain and the two together can improve performance as well as promoting recovery from injury.Tue, 19 Feb 2013 20:15:15 ESThttp://www.sciencedaily.com/releases/2013/02/130219201523.htmhttp://www.sciencedaily.com/releases/2013/02/130219172159.htm Researchers believe they have discovered a biological marker of dyslexia, a disorder affecting up to one out of 10 children that makes learning to read difficult. The researchers found a systematic relationship between reading ability and the consistency with which the brain encodes sounds. The good news: Response consistency can be improved with auditory training.Tue, 19 Feb 2013 17:21:21 ESThttp://www.sciencedaily.com/releases/2013/02/130219172159.htm

Source: http://www.sciencedaily.com/rss/mind_brain/child_development.xml

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Tone Loc Collapses on Stage in Iowa

Source: http://www.thehollywoodgossip.com/2013/03/tone-loc-collapses-on-stage-in-iowa/

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Aviary Launches Its Photo Editing SDK For Windows 8 Thanks To AMD Ventures Investment

Aviary, the company that provides a fully customizable SDKs for applications that want to include photo editing, has announced the launch of its Windows 8 SDK in collaboration with AMD and Microsoft. This means that apps for Windows 8 PCs and tablets that run AMD processors can start including photo editing immediately. The company has already gotten serious traction by being included within Flickr, Twitter, Photobucket and thousands of other apps, so Windows 8 was a logical move for them. The collaboration is actually backed by an investment from AMD Ventures, which came in its last round. AMD would clearly love to see popular photo apps crop up on the Windows platform. Since social photo editing is such a popular behavior on the web these days, not having a platform to easily deploy the feature within apps left a massive hole in the Windows app store. To pump up the partnership, Manju Hegde, an AMD VP, referred to Aviary as “the standard in mobile and online photo editing,” something we’ve said about the company before. As far as the investment, Hegde shared “AMD is committed to supporting the future of industry changing innovators like Aviary, through investment by AMD Ventures and by enhancing user experiences on our award-winning APU platforms.? AMD was involved in Aviary’s last funding round, which also included Spark and Bezos Expeditions, so these resources have clearly come to fruition. The SDK for Windows 8 is available now and comes with enough documentation and examples to shake a stick at. Aviary also has released its first Windows 8 app through the Windows Store to showcase the features and functionality of the Aviary SDK for Windows 8. The company has also launched a photo editor itself in the Windows Store, to show off the type of functionality that developers can now leverage for their own apps. Aviary says that with the AMD APUs, effects can be processed up to 16X faster than on other processors, an advantage of working directly with AMD. Said Aviary CEO, Tobias Peggs: AMD’s APUs allow us to enable the most processor-intensive photo effects we have ever been able to offer. They’ve helped to push our technology forward, and in turn, end users can push the limits of their creativity even further. Along with Windows 8, Aviary’s SDK is available for iOS, Android, Windows Phone 7 and HTML5. Its launch partners for Windows 8

Source: http://feedproxy.google.com/~r/Techcrunch/~3/JUmmc096hGs/

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Best Home Shop Market: The Beginners Guide To Woodworking ...

Woodworking is great since it can be a hobby as well as a profession. You can make plenty of money on woodworking projects if you're talented. You can build armchairs, tables, beds and many other things and if you build really nice things?you will be able to sell them.

The great thing with the woodworking craft is that it can give families with low income the possibility to have some really nice furniture as well as other things in their homes since they will be able to create these items with their own hands. It takes time to become really skillful of course but everyone has to start somewhere in order to become successful. It's never too late to start working with woodworking projects and it's a fun hobby to practice as well.?

If you're interested in learning ?more about the woodworking craft you should definitely perform some research on the net. You will be able to find plenty of useful tips there and you will soon be able to start practice what you've learned. You can also get much help if you become member of a forum on the net where woodworking craft is discussed.?

When you've read a few guidance articles online you will know that you need some basic woodworking tools when you want to start working on your woodworking plans. A saw is a tool that you can't live without if you want to become a woodworking talent. You will need more than one saw, at least two saws, perhaps more. You also need to buy at least one jig and a knife is always good to have as well. These tools are the basic things you need to have to get started but you might have to buy a few other tools as well when you proceed to more advanced woodworking projects.?

The woodworking craft is a hobby that can be very satisfying. It feels great to know that you've built the nice things that you have in your home and your family will most likely be very happy about it as well. This is a great hobby to have and it can become your profession one day if you spend enough time on it.?

It's a great feeling to be able to build something from wood with your own hands. You can come up with new woodworking plans every month and finish them as soon as you have some time off from work.

Source: http://besthomeshop4u.blogspot.com/2013/03/the-beginners-guide-to-woodworking.html

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EBay Instant Sale shut down. Three alternatives.

EBay Instant Sale's end means one less outlet for consumers to trade in their old electronics. But there are still a few viable options.?

By Emily Dovi,?Contributor / March 17, 2013

Bostonians cashed in their tech at the eBay Instant Sale Truck, shown last year in Cambridge, Mass. EBay shut down the program earlier this month.

Bizuayehu Tesfaye/AP Images for eBay Instant Sale/File

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If you want to trade in, say, an old cell phone, you can weigh its estimated resale value from a host of electronics recycling programs. But the number of these services has recently shrunk. The ever-popular Gazelle last year changed the type of gadgets it accepts to focus almost exclusively on more profitable Apple products, and just two weeks ago, eBay?shut down its Instant Sale program.

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Launched in October 2010 and grown from the idea of "resell, reuse, recycle," eBay Instant Sale partnered with reputable third-party AllTechWholesale to resell electronics purchased directly from eBay customers. Instant Sale offered consumers immediate quotes and payments for their electronics, which seemed to compliment the site's reputation for auctions and buy-it-now sales. All in all, the service had made 4 million offers in the United States since 2011. But it would appear that eBay's recent rebranding efforts aimed at generating a "more simplified and personalized selling experience" have at least temporarily suspended the trade-in program.

Even with the absence of Instant Sale, there are still a number of reputable and competitive electronics recycling services available. Consumers can still turn to the likes of NextWorth, Glyde, Amazon, and specific electronics manufacturers (like HP, Sony, and Toshiba, to name a few) for competitive resale prices on old electronics. Moreover, a Google Shopping-esque site called Flipsy launched recently, that allows users to compare trade-in offers across several sites in one fell swoop.

On the flip side of the resale market, will the shuttering of Instant Sale make it more difficult to find a deal on a refurbished or used iPad on eBay? Unlikely, as a not-so-mysterious-anymore eBay store has been undercutting Apple's own prices on refurbished devices. But having one less outlet for selling off and re-using recycled devices could mean an overstock of obsolete electronics in other outlets and subsequently less cash in hand for consumers looking to trade up to current- and future- generation devices.

What do you think, readers? Have you traded-in any old electronics via NextWorth, Gazelle, or Instant Sale? Do you think the absence of an eBay trade-in program will affect the stock of used and refurbished devices available for purchase in the long run?

This article first appeared in dealnews.com

Source: http://rss.csmonitor.com/~r/feeds/csm/~3/9DicPNGmW00/EBay-Instant-Sale-shut-down.-Three-alternatives.

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